Seven young women (aged 18–47yrs) working in a paint factory and exposed to nanoparticles for 5–13months fell ill and were admitted to hospital. Two subsequently died. Pathological examinations of the patients' lung tissue showed nonspecific inflammation, fibrosis and foreign-body granulomas (tumours resulting from inflammation) of the pleura (membrane around the lungs). Transmission electron microscopy revealed nanoparticles of polyacrylate lodged in the cytoplasm and the nucleus of cells and in the chest fluid . The polyacrylate nanoparticles were confirmed in the workplace.
These first suspected cases of nanotoxicity from occupational exposure have heightened concerns over the huge and rapidly expanding array of nanotechnology products in the market that remains unregulated despite accumulating evidence that many nano-ingredients, including those most common in commercial use, are indeed toxic. [Fonte: ISIS]